The number of pupils entered for the combined science GCSE this year has fallen by 27.6 per cent.
There were only 960 entries for pupils aged 15 and under for GCSE sciences in comparison to 141,414 last year - showing a drop of 99.3 per cent.
Schools used to enter pupils for combined science at the end of Year 10 and additional science at the end of Year 11.
However, Ofqual said this summer that many pupils who would normally have sat the exam at the age of 15 were waiting until next year to take the new 9 to 1 combined science or 9 to 1 separate sciences.
Figures also show that the proportion of A* to C grades in GCSE science has fallen by 4.9 percentage points compared to last year.
The proportion of A* to A grades dropped by 1.8 percentage points compared to 2016.
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